FROM EXPERIMENT TO MEDICINAL SUBSTANCES
Long-term investigations performed by the research team of the Institute resulted in creating a new class of geroprotectors – peptide bioregulators. The administration of peptide bioregulators enables effective prevention of premature ageing and therapy of age-related diseases.
Researchers of the Institute are the inventors of a number of medicinal and prophylactic pharmaceutical substances, which have been adopted by the Russian Ministry of Public Health and are presently under serial production:
* 6 geroprotective medications (Thymalin, Thymogen, Epithalamin, Prostatilen, Cortexin,
* 30 types of cell metabolism bioregulators,
* 5 highly efficient synthesized peptides (Vilon, Epitalon, Cortagen, Livagen, Prostamax),
which largely have no analogues in other countries.
There were chemically synthesized over 100 biologically active peptides which revealed the ability to hold back the process of ageing.
According to the concept of peptide bioregulation, a theory of endogenous peptide bioregulators’ involvement in the maintenance of structural and functional homeostasis of cell populations, containing and producing these factors, was formulated. These endogenous peptides became commonly known as “Cytomedins”.
Cytomedins control gene expression and protein synthesis, thus preventing age-related accumulation of quantitative structural and functional alterations, which are the markers of transition of a biological system from the norm to the pathology. Disordered peptide bioregulation reduces organism resistance to external and internal destabilizing factors, serving a cause of premature ageing.
A long record of peptide bioregulators application in the health service has demonstrated their high effectiveness in combating various disease and pathologies, including those refractory to other medicines.
The researchers developed a new technology for creating biologically active food supplements (parapharmaceuticals), based on peptide complexes isolated from animal organs and tissues. A new group of parapharmaceuticals has received a name of “Cytomaxes”. Biologically active food supplements are produced in the form of tablets and capsules. Cytomaxes exert a regulatory effect on the cellular level and are used for improving the organism resistance to the impact of adverse environmental, climatic, occupational and other factors, as well as during the rehabilitation period after surgeries, traumas, diseases; in case of malnutrition, high physical loads; for the purpose of maintaining the functions of the main organism systems in old and very old persons in order to reduce the risk of disease occurrence.
CYTOMAXES – NATURAL PEPTIDE COMPLEXES (PARAPHARMACEUTICALS)
CERLUTEN® brain bioregulator Correction of central nervous system functions
THYREOGEN® thyroid gland bioregulator Correction of endocrine system functions
VENTFORT® vessels bioregulator Correction of cardiovascular system functions
SIGUMIR® cartilaginous tissue bioregulator Correction of locomotor apparatus functions
SVETINORM® liver bioregulator Correction of digestive system functions
SUPREFORT® pancreas bioregulator Correction of digestive system functions
VLADONIX® thymus bioregulator Correction of immune system functions
One of the recent achievements of the Institute is a technology for synthesizing from amino acids a new group of bioregulators – “Cytogens”. Cytogens are peptide pharmaceuticals and parapharmaceuticals, which exert a pronounced regulatory effect on protein biosynthesis in the cells
CYTOGENS – SYNTHESIZED PEPTIDES (PHARMACEUTICALS AND PARAPHARMACEUTICALS)
PINEALON® -synthesized brain peptide- Correction of central nervous system functions
VESUGEN® -synthesized vessels peptide- Correction of cardiovascular system functions
CARDIOGEN® -synthesized vessels peptide- Correction of cardiovascular system functions
CARTALAX® -synthesized cartilaginous tissue peptide- Correction of locomotor apparatus functions
OVAGEN® -synthesized liver peptide- Correction of liver functions
CHONLUTEN® -synthesized lungs peptide- Correction of respiratory system functions
BRONCHOGEN® -synthesized bronchial peptide- Correction of respiratory system functions
PANCRAGEN® -synthesized pancreas peptide- Correction of carbohydrate metabolism
CRYSTAGEN® -synthesized thymus peptide- Correction of immune system functions
TESTAGEN® -synthesized testis peptide- Correction of male sexual functions
On the basis of the natural peptide complexes, the Institute researchers developed a new class of medicinal substances – “Peptomaxes”. These medicinal substances significantly improve the effectiveness of standard methods of organism rehabilitation after the impact of different adverse factors (traumas, irradiation, intoxication, infection, psychoemotional stress). They are used for preventing and correcting different conditions, which are accompanied by disordered organism resistance and some physiological functions, as well as in age-related pathology.
PEPTOMAXES – NATURAL POLYPEPTIDE COMPLEXES (PHARMACEUTICALS)
BRAIN EXTRACT -Correction of central nervous system functions-
PINEAL GLAND EXTRACT -Correction of endocrine system functions-
THYROID GLAND EXTRACT -Correction of endocrine system functions-
VESSELS EXTRACT -Correction of cardiovascular system functions-
CARTILAGES EXTRACT -Correction of locomotor apparatus functions-
LIVER EXTRACT -Correction of digestive system functions-
KIDNEYS EXTRACT -Correction of urogenital system functions-
TESTIS EXTRACT -Correction of urogenital system functions-
OVARIES EXTRACT -Correction of urogenital system functions-
URNARY BLADDER EXTRACT -Correction of urogenital system functions-
RETINAL EXTRACT -Correction of visual functions-